Our lab is devoted to the development of novel strategies for accurate and quantitative biomedical measurements. We would like to bring the precision measurement tradition from physics to biology and medicine, hoping to make discoveries that were previously unreachable with qualitative methods. To achieve our goal, we integrate a wide breadth of techniques, including microfluidics and genomics. As the biological equivalent of the integrated circuit, microfluidic large scale integration enables the manipulation of very small volume of fluids. We now routinely perform on-chip single-cell or even single-molecule analysis, which was previously hindered by the cumbersome benchtop devices. New genomic technologies, such as digital PCR and DNA sequencing, not only have revolutionized the field of genetics, but also provided new tools for precise measurements. In contrast to the fast development of various technologies, their adaptation in traditional biology fields is quite slow. While the difficulty to master these new technologies hampers the quantitative biology revolution, we deem the lack of new measurable targets for the same biological phenomenon as the genuine obstacle in this revolutionary process. My previous work in prenatal diagnosis and germ line genomics has taught us that measuring a different facet of the same object, with the support from new technologies, could lead us to great discoveries. We are now applying this new way of research to human genetics, developmental biology, cancer biology and immunology.